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说明书COAMSDS
Recombinant Human B7H3/CD276 Protein, Avi-His
B7 homolog 3 (B7-H3, CD276), an immunoglobulin superfamily member, comprises two Ig-like C2-type and two Ig-like V-type domains. It modulates T-cell immune responses, protects tumor cells from NK cell-mediated lysis, and serves as a biomarker for neuroblastoma. B7-H3 also contributes to acute and chronic transplant rejection, regulates mucosal lymphocyte function, and supports the immune tolerance required for placental and fetal survival during pregnancy.
| 分子别名（Synonyms） | B7-H3, CD276, B7 homolog 3 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | ·Recombinant Human (Uniprot: Q5ZPR3-1) B7H3 Protein is expressed from HEK293 cells with Avi-His tag at the C-terminus.It contains AA Leu 29- Gly 245.·The protein has a predicted MW of 26.8 kDa. The protein migrates as 35-45 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| 内毒素（Endotoxin） | < 0.1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 90% as determined by SDS-PAGE |
| 浓度及缓冲液（Concentration ＆ Formulation） | ·1.5 mg/mL·Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| 靶点背景 | B7 homolog 3 (B7-H3, CD276), an immunoglobulin superfamily member, comprises two Ig-like C2-type and two Ig-like V-type domains. It modulates T-cell immune responses, protects tumor cells from NK cell-mediated lysis, and serves as a biomarker for neuroblastoma. B7-H3 also contributes to acute and chronic transplant rejection, regulates mucosal lymphocyte function, and supports the immune tolerance required for placental and fetal survival during pregnancy. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
告诉我们预期应用与现有起始材料，我们会评估可行性、匹配合适的技术路线，并给出定制报价，通常一个工作日内由科学家直接回复。
