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说明书COAMSDS
Recombinant Human SIGLEC6/ CD327 Protein, Alpaca Fc
SIGLEC6, a member of the immunoglobulin superfamily and SIGLEC family of sialic acid-binding Ig-like lectins, is abundantly expressed in placental cytotrophoblasts and syncytiotrophoblasts, with weaker expression in the spleen, intestinal tissue and peripheral B-cell-dominant leukocytes. It distributes across cell membranes and extracellular spaces. Its expression rises during and after labor, putatively delaying labor progression, and is further elevated in pre-eclampsia—a human-specific disorder.
| 分子别名（Synonyms） | SIGLEC6, CD327, CD33L, CD33L1, OBBP1, OB-BP1, CDw327 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | ·Recombinant Human(Uniprot: O43699-3) SIGLEC6 Protein is expressed from HEK293 cells with Alpaca Fc tag at the C-terminus.It contains AA Gln 27- Val 331.·The protein has a predicted MW of 60.4 kDa. The protein migrates as 70-85 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| 内毒素（Endotoxin） | < 0.1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 95% as determined by SDS-PAGE. |
| 浓度及缓冲液（Concentration ＆ Formulation） | ·1.21 mg/mL ·Filtered through a 0.22 μm filter, stored in 25 mM Sodium Citrate, 1x PBS,pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| 靶点背景 | SIGLEC6, a member of the immunoglobulin superfamily and SIGLEC family of sialic acid-binding Ig-like lectins, is abundantly expressed in placental cytotrophoblasts and syncytiotrophoblasts, with weaker expression in the spleen, intestinal tissue and peripheral B-cell-dominant leukocytes. It distributes across cell membranes and extracellular spaces. Its expression rises during and after labor, putatively delaying labor progression, and is further elevated in pre-eclampsia—a human-specific disorder. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
告诉我们预期应用与现有起始材料，我们会评估可行性、匹配合适的技术路线，并给出定制报价，通常一个工作日内由科学家直接回复。
