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说明书COAMSDS
Recombinant Human OSMR/ IL-31R-beta Protein, Alpaca Fc
OSMR (IL-31RB), a type I cytokine receptor, is an oncostatin M receptor subunit. It heterodimerizes with IL-6 signal transducer or IL-31 receptor A to form functional receptors for oncostatin M and IL-31, respectively, and transduces their signaling. OSMR mutations cause hereditary primary localized cutaneous amyloidosis type 1 (PLCA1, familial lichen amyloidosis), featuring localized skin amyloid deposition, lower-limb pruritus, hyperpigmentation and lichenification worsened by persistent scratching. Amyloid deposits consist of degraded keratin filaments, serum amyloid P component and immunoglobulins.
| 分子别名（Synonyms） | ：Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB,OSMR,OSMRB |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | ·Recombinant Human(Uniprot: Q99650-1) OSMR Protein is expressed from HEK293 cells with Alpaca Fc tag at the C-terminus.It contains AA Glu 28- Met 740.·The protein has a predicted MW of 84.7 kDa. The protein migrates as 35-45 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| 内毒素（Endotoxin） | < 0.1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 90% as determined by SDS-PAGE. |
| 浓度及缓冲液（Concentration ＆ Formulation） | ·2.56 mg/mL ·Filtered through a 0.22 μm filter, stored in 25 mM Sodium Citrate, 1x PBS,pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| 靶点背景 | OSMR (IL-31RB), a type I cytokine receptor, is an oncostatin M receptor subunit. It heterodimerizes with IL-6 signal transducer or IL-31 receptor A to form functional receptors for oncostatin M and IL-31, respectively, and transduces their signaling. OSMR mutations cause hereditary primary localized cutaneous amyloidosis type 1 (PLCA1, familial lichen amyloidosis), featuring localized skin amyloid deposition, lower-limb pruritus, hyperpigmentation and lichenification worsened by persistent scratching. Amyloid deposits consist of degraded keratin filaments, serum amyloid P component and immunoglobulins. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
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