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说明书COAMSDS
Recombinant Human CDH3/CDHP Protein, Alpaca Fc
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
| 分子别名（Synonyms） | CDH3, CDHP, Cadherin-3, Placental-cadherin |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | ·Recombinant Human(Uniprot: P22223-1) CDH3 Protein is expressed from HEK293 cells with Alpaca Fc tag at the C-terminus.It contains AA Asp 108- Gly 654.·The protein has a predicted MW of 86.7 kDa. The protein migrates as 120-140 kDa when calibrated against under reducing (R) condition (SDS- PAGE) due to glycosylation. |
| 内毒素（Endotoxin） | < 0.1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 90% as determined by SDS-PAGE. |
| 浓度及缓冲液（Concentration ＆ Formulation） | ·0.42 mg/mL ·Filtered through a 0.22 μm filter, stored in 25 mM Sodium Citrate, 1x PBS,pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| 靶点背景 | Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
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