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说明书COAMSDS
Recombinant Human B7H4/VTCN1 Protein, Alpaca Fc
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1/B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
| 分子别名（Synonyms） | B7H4, B7-H4, VTCN1, B7S1, B7h.5 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | ·Recombinant Human (Uniprot: Q7Z7D3-1) B7H4 Protein is expressed from HEK293 cells with Avi-His tag at the C-terminus.It contains AA Phe 29- Ala 258.·The protein has a predicted MW of 52 kDa. The protein migrates as 70-85 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation |
| 内毒素（Endotoxin） | < 0.1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 90% as determined by SDS-PAGE. |
| 浓度及缓冲液（Concentration ＆ Formulation） | ·1.94 mg/mL·Filtered through a 0.22 μm filter, stored in 25 mM Sodium Citrate, 1x PBS,pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| 靶点背景 | V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1/B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
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