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说明书COAMSDS
Recombinant Human CD38/ T10 Protein, Avi-His
CD38 (ADP-ribosyl cyclase 1) is an ADP-ribosyl cyclase family protein highly expressed in multiple normal tissues, lymphoma and neuroblastoma. This multifunctional ectoenzyme mediates cyclic ADP-ribose (cADPR) metabolism from NAD+ to ADP-ribose, governing intracellular Ca2+ homeostasis. CD38 dysfunction causes immune and metabolic defects alongside behavioral changes. As a cell activation marker, it is associated with HIV, hematologic and solid tumors, type 2 diabetes and bone metabolism, and serves as a prognostic biomarker for leukemia.
| 分子别名（Synonyms） | CD38, T10, cADPr hydrolase 1 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | ·Recombinant Human(Uniprot: P28907-1) CD38 Protein is expressed from HEK293 cells with Avi-His tag at the C-terminus.It contains AA Val 43- Ile 300.·The protein has a predicted MW of 33.4 kDa. The protein migrates as 35-45 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| 内毒素（Endotoxin） | < 0.1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 95% as determined by SDS-PAGE. |
| 浓度及缓冲液（Concentration ＆ Formulation） | ·1.51 mg/mL ·Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | ·This product is shipped under low-temperature conditions. Avoid repeated freeze-thaw cycles during handling.·Protein solution can be stored at 2-8°C for 2-7 days.·Samples are stable for 3 months from date of receipt at -20℃ /-80℃. ·Recommend to aliquot the protein into smaller quantities for optimal storage. |
| 靶点背景 | CD38 (ADP-ribosyl cyclase 1) is an ADP-ribosyl cyclase family protein highly expressed in multiple normal tissues, lymphoma and neuroblastoma. This multifunctional ectoenzyme mediates cyclic ADP-ribose (cADPR) metabolism from NAD+ to ADP-ribose, governing intracellular Ca2+ homeostasis. CD38 dysfunction causes immune and metabolic defects alongside behavioral changes. As a cell activation marker, it is associated with HIV, hematologic and solid tumors, type 2 diabetes and bone metabolism, and serves as a prognostic biomarker for leukemia. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
告诉我们预期应用与现有起始材料，我们会评估可行性、匹配合适的技术路线，并给出定制报价，通常一个工作日内由科学家直接回复。
