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说明书COAMSDS
Human CD19 Protein (20-556, VLP)
B-lymphocyte antigen CD19 is a single-pass type I membrane protein containing two Ig-like C2 domains. It is expressed on follicular dendritic cells and B cells throughout development until blast stage, but is absent on plasma cells. As a B-cell co-receptor with CD21 and CD81, its phosphorylated cytoplasmic tail recruits Src-family kinases and PI-3 kinase upon activation.
| 分子别名（Synonyms） | CD19, B4, CVID3 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | •(Uniprot: P15391-1) Human CD19 Protein (VLP) is expressed from HEK293 cells with V5 tag at the N-terminus and Avi-His tag at the C-terminus. It contains AA Pro 20 - Arg 556. |
| 分子表征（Molecular Characterization） | Envelope virus-like particles (eVLPs) are produced by co-expressing membrane proteins and viral structural proteins in mammalian cells. Membrane antigens are natively embedded into lipid bilayers during budding, maintaining native conformation and PTMs. |
| 内毒素（Endotoxin） | < 1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 95 % as determined by DLS. |
| 浓度及缓冲液（Concentration ＆ Formulation） | •0.99 mg/mL•Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | This product is supplied and shipped on dry ice.•Samples are stable for 3 months from date of receipt at -80℃.•Recommend to aliquot the protein into smaller quantities for optimal stora- ge. Please avoid repeated freeze-thaw cycles. |
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| 靶点背景 | B-lymphocyte antigen CD19 is a single-pass type I membrane protein containing two Ig-like C2 domains. It is expressed on follicular dendritic cells and B cells throughout development until blast stage, but is absent on plasma cells. As a B-cell co-receptor with CD21 and CD81, its phosphorylated cytoplasmic tail recruits Src-family kinases and PI-3 kinase upon activation. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
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