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说明书COAMSDS
Cynomolgus macaque CLDN1 Full Length Protein (VLP)
Claudin-1 (CLDN1) is a four-transmembrane tight junction protein. Aberrant overexpression and cell-surface exposure of non-junctional CLDN1 are observed in multiple cancers, driving tumor invasion, metastasis and immune suppression. As a promising therapeutic target for antibodies, ADCs and bispecifics, CLDN1 is suitable for immunotherapeutic discovery. We supply high-quality CLDN1 recombinant protein, membrane antigen and CLDN1-displaying VLPs to support antibody screening, binding assessment and preclinical validation.
| 分子别名（Synonyms） | CLD1, ILVASC, SEMP1 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | •(Uniprot: A0A2K5WWF3) Cynomolgus macaque CLDN1 Full Length Protein (VLP) is expressed from HEK293 cells. It contains AA Met 1 - Val 211. |
| 分子表征（Molecular Characterization） | Envelope virus-like particles (eVLPs) are produced by co-expressing membrane proteins and viral structural proteins in mammalian cells. Membrane antigens are natively embedded into lipid bilayers during budding, maintaining native conformation and PTMs. |
| 内毒素（Endotoxin） | < 1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 95 % as determined by DLS. |
| 浓度及缓冲液（Concentration ＆ Formulation） | •0.78 mg/mL•Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | This product is supplied and shipped on dry ice.•Samples are stable for 3 months from date of receipt at -80℃.•Recommend to aliquot the protein into smaller quantities for optimal stora- ge. Please avoid repeated freeze-thaw cycles. |
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| 靶点背景 | Claudin-1 (CLDN1) is a four-transmembrane tight junction protein. Aberrant overexpression and cell-surface exposure of non-junctional CLDN1 are observed in multiple cancers, driving tumor invasion, metastasis and immune suppression. As a promising therapeutic target for antibodies, ADCs and bispecifics, CLDN1 is suitable for immunotherapeutic discovery. We supply high-quality CLDN1 recombinant protein, membrane antigen and CLDN1-displaying VLPs to support antibody screening, binding assessment and preclinical validation. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
告诉我们预期应用与现有起始材料，我们会评估可行性、匹配合适的技术路线，并给出定制报价，通常一个工作日内由科学家直接回复。
