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Human GPRC5D Full Length Protein (VLP)
GPRC5D is an orphan G protein-coupled receptor exhibiting tightly restricted expression predominantly in malignant plasma cells, alongside limited expression in hard keratinized tissues including hair and nail. This unique expression pattern minimizes off-tumor on-target toxicity, rendering GPRC5D a promising and transformative target for bispecific antibodies and CAR-T cell therapies to treat relapsed and refractory multiple myeloma.
| 分子别名（Synonyms） | G-protein coupled receptor family C group 5 member D |
|---|---|
| 蛋白结构及表达系统（Protein Construction ＆ Source） | •(Uniprot: Q9NZD1-1)Human GPRC5D Full Length Protein (VLP) is expressed from HEK293 cells with V5 tag at the N-terminus. It contains AA Met 1 - Val 345. |
| 分子表征（Molecular Characterization） | Envelope virus-like particles (eVLPs) are produced by co-expressing membrane proteins and viral structural proteins in mammalian cells. Membrane antigens are natively embedded into lipid bilayers during budding, maintaining native conformation and PTMs. |
| 内毒素（Endotoxin） | < 1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 95 % as determined by DLS. |
| 浓度及缓冲液（Concentration ＆ Formulation） | •0.6 mg/mL •Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | This product is supplied and shipped on dry ice. •Samples are stable for 3 months from date of receipt at -80℃. •Recommend to aliquot the protein into smaller quantities for optimal stora- ge. Please avoid repeated freeze-thaw cycles. |
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| 靶点背景 | GPRC5D is an orphan G protein-coupled receptor exhibiting tightly restricted expression predominantly in malignant plasma cells, alongside limited expression in hard keratinized tissues including hair and nail. This unique expression pattern minimizes off-tumor on-target toxicity, rendering GPRC5D a promising and transformative target for bispecific antibodies and CAR-T cell therapies to treat relapsed and refractory multiple myeloma. |
|---|---|
| 别名 | G-protein coupled receptor family C group 5 member D |
仅供科研使用。不可用于临床诊断、治疗或人体。
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