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说明书COAMSDS
Human CCR6 Full Length Protein (VLP)
CCR6 (C-C motif chemokine receptor 6, CD196) is a class A seven-transmembrane G protein-coupled receptor (GPCR). It recognizes CCL20 (MIP-3α) as its primary endogenous ligand, mediating leukocyte chemotaxis and mucosal immune homeostasis; the CCR6-CCL20 axis is a well-validated target for autoimmune and inflammatory disease research.
| 分子别名（Synonyms） | BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | •(Uniprot: P51684-1) Human CCR6 Full Length Protein (VLP) is expressed from HEK293 cells with V5 tag at the N-terminus and Avi-His tag at the C-terminus. It contains AA Met 1 - Met 374. |
| 分子表征（Molecular Characterization） | Envelope virus-like particles (eVLPs) are produced by co-expressing membrane proteins and viral structural proteins in mammalian cells. Membrane antigens are natively embedded into lipid bilayers during budding, maintaining native conformation and PTMs. |
| 内毒素（Endotoxin） | < 1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 95 % as determined by DLS. |
| 浓度及缓冲液（Concentration ＆ Formulation） | •2 mg/mL•Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | This product is supplied and shipped on dry ice.•Samples are stable for 3 months from date of receipt at -80℃.•Recommend to aliquot the protein into smaller quantities for optimal stora- ge. Please avoid repeated freeze-thaw cycles. |
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| 靶点背景 | CCR6 (C-C motif chemokine receptor 6, CD196) is a class A seven-transmembrane G protein-coupled receptor (GPCR). It recognizes CCL20 (MIP-3α) as its primary endogenous ligand, mediating leukocyte chemotaxis and mucosal immune homeostasis; the CCR6-CCL20 axis is a well-validated target for autoimmune and inflammatory disease research. |
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仅供科研使用。不可用于临床诊断、治疗或人体。
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