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说明书COAMSDS
Human CD37 Full Length Protein (VLP)
CD37 (Tetraspanin-26) is a four-transmembrane integral membrane glycoprotein belonging to the tetraspanin superfamily. It is selectively expressed on mature B lymphocytes, participates in the assembly of tetraspanin-enriched membrane microdomains and B‑cell survival signaling, and serves as a validated therapeutic target for B-cell malignancies including non-Hodgkin lymphoma and chronic lymphocytic leukemia.
| 分子别名（Synonyms） | CD37, Tspan-26, TSPAN26 |
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| 蛋白结构及表达系统（Protein Construction ＆ Source） | •(Uniprot: P11049)Human CD37 Full Length Protein (VLP) is expressed from HEK293 cells with His-Flag tag at the C-terminus. It contains AA Met 1 - Arg 281. |
| 分子表征（Molecular Characterization） | Envelope virus-like particles (eVLPs) are produced by co-expressing membrane proteins and viral structural proteins in mammalian cells. Membrane antigens are natively embedded into lipid bilayers during budding, maintaining native conformation and PTMs. |
| 内毒素（Endotoxin） | < 1 EU per ug as determined by the LAL method. |
| 纯度（Purity） | > 95 % as determined by DLS. |
| 浓度及缓冲液（Concentration ＆ Formulation） | •1.01 mg/mL•Filtered through a 0.22 μm filter, stored in 1x PBS, pH 7.4. |
| 运输及储存（Transportation ＆ Storage） | This product is supplied and shipped on dry ice.•Samples are stable for 3 months from date of receipt at -80℃.•Recommend to aliquot the protein into smaller quantities for optimal stora- ge. Please avoid repeated freeze-thaw cycles. |
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| 靶点背景 | CD37 (Tetraspanin-26) is a four-transmembrane integral membrane glycoprotein belonging to the tetraspanin superfamily. It is selectively expressed on mature B lymphocytes, participates in the assembly of tetraspanin-enriched membrane microdomains and B‑cell survival signaling, and serves as a validated therapeutic target for B-cell malignancies including non-Hodgkin lymphoma and chronic lymphocytic leukemia. |
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